Wet Laboratory
Pathognomics operates a laboratory focused on cellular pathology that utilises the following techniques:
Specimen Dissection
Specimen dissection is carried out by a trained biomedical scientist with support from a clinical team as required.
Processing
Pathognomics has two Epredia Processors with programmes capable of;
- Overnight Processing
- Urgent Biopsies
- Fatty and large blocks
- Weekend programme
Embedding
Embedding is prepared on a Leica embedding centre with heated forceps.
Section Cutting
A Thermo Scientific Finesse Microtome and Epredia HM340E microtomes are used for all section cutting.
Slide Scanning
We use an IV-CE accredited Hamamatsu slide scanner to scan both small and large slides. We have both the NanoZoomer S60 and two S360s which facilitates both brightfield and fluorescence imaging.
H&E Staining
All automated staining is carried out on a DAKO CoverStainer.
Special Stains
We currently offer a full range of special stains:
- Alcian Blue, Alcian Blue PAS, Alcian Blue DPAS
- Congo Red
- EVG
- Gram
- Grocott
- Hexamine
- HVG
- Masson Trichrom, Masson Fontana
- MSB
- Oil Red O
- Orcein
- PAS, PAS D
- Perls
- Retic
- Von Kossa
- ZN
Immunohistochemistry
At Pathognomics all of our IHC is carried out on a Roche Ventana BenchMark XT utilising the following antibodies (antibodies in bold are on our UKAS ISO 15189 schedule):
- Beta Catenin
- BerEP4
- Calretinin
- CD3, CD8, CD10, CD20, CD 30, CD31, CD34, CD45, CD56, CD68, CDX2
- Chromogranin A
- CK5/6, CK7, CK20
- D2-40
- Desmin
- EMA
- ER
- HMB45
- H-Pylori
- Melan A
- MLH1
- MOC-31
- HSA
- MSH2
- P16, P53, P63
- Pan Keratin
- PSA
- PSAP
- S100
- SMA
- SOX10
- Synaptophysin
- TFF3
- TTF1
- Vimentin
- WTI
Specialities
At Pathognomics our team of expert pathologists cover a wide range of specialities:
- Breast Pathology
- Dermatopathology
- Endocrine Pathology
- Genitourinary Pathology
- Gastrointestinal Pathology
- Gynecological Pathology
- Haematopathology
- Head & Neck and ENT Pathology
- Lung Pathology
- Oral Pathology
- Paediatric Pathology
- Perinatal Pathology
- Renal Pathology
If you have any questions regarding our team of pathologists or the services that we provide, please contact us here.